Novel liver macromolecular MR contrast agent with a polypropylenimine diaminobutyl dendrimer core: Comparison to the vascular MR contrast agent with the polyamidoamine dendrimer core
نویسندگان
چکیده
منابع مشابه
Novel intravascular macromolecular MRI contrast agent with generation-4 polyamidoamine dendrimer core: accelerated renal excretion with coinjection of lysine.
One of the major limitations to macromolecular MRI contrast agents (MRI-CAs) is their slow clearance and associated decreased excretion of gadolinium (Gd(III)). The effect of coinjecting lysine to accelerate renal excretion of a macromolecular MRI-CA (generation-4 PAMAM dendrimer (G4D-(1B4M-Gd)64)) was investigated. The biodistribution and urine and fecal excretion in athymic mice was evaluated...
متن کاملRecent Advances in PET-MR Hybrid contrast agent
Introduction: All of the Imaging modalities have advantages and disadvantages alone. So if we want to have the best and perfect image, combining these modalities produces something we desired. PET-MR images consist of morphologic and metabolic data. MRI and PET provide high spatial and contrast resolution and high sensitivity and molecular information respectively. Hybrid PET-...
متن کاملComparison of MR lymphangiography with a G6 macromolecular contrast agent obtained at 1.5T and 3.0T Systems
Y. Hama, M. Bernardo, Y. Koyama, C. A. Regino, M. W. Brechbiel, P. L. Choyke, H. Kobayashi Molecular Imaging Program, NCI/NIH, Bethesda, Maryland, United States, Molecular Imaging Program, SAIC-Frederick, NCI/NIH, Bethesda, Maryland, United States, Radiation Oncology Branch, NCI/NIH, Bethesda, Maryland, United States Introduction Higher field strength magnets are theoretically superior in signa...
متن کاملInhaled oxygen: a brain MR contrast agent?
Oxygen inhalation led to subtle but readily detectable changes on T2*-weighted images with a conventional MR imager at 1.5 T. We attribute the increase in local signal intensity to changes in blood oxygenation, in particular to a net conversion of deoxyhemoglobin to oxyhemoglobin.
متن کامل3D-liver perfusion MR imaging with MS-325 blood pool contrast agent to evaluate liver fibrosis
Introduction Liver fibrosis is an important cause of mortality and morbidity in patients with chronic liver diseases. Fibrosis can lead to cirrhosis from which the complications involve 15,000 deaths per year in France [1]. Recently, the studies about the mechanism of hepatic fibrogenesis have shown the reversible aspect of liver fibrosis and have allowed the emergence of more effective treatme...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2001
ISSN: 0740-3194,1522-2594
DOI: 10.1002/mrm.1259